Last week, Dr. Monica Bertagnolli accepted recommendations from the Advisory Committee to the NIH Director on considering approaches that use novel alternative methods in biomedical and behavioral research. This is an exciting step in our ongoing efforts to support research that complements traditional models when scientifically feasible.
NIH’s Rigor and Reproducibility FAQs have been updated with new questions and answers about authenticating key biological/chemical resources.
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The NIH office of Laboratory Animal Welfare (OLAW) released a webinar recording on how the NC3Rs Experimental Design Assistant (EDA) can assist researchers plan for their studies involving animals.
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Earlier this month, we released a Request for Information seeking public input on the humane care and use of laboratory cephalopods at Assured institutions. The proposed guidance acknowledges the evidence suggesting these animals would benefit from oversight, but also that there are not yet specific care and use standards to allow them to be regulated under the Public Health Service Policy for the Humane Care and Use of Laboratory Animals.
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As NIH has been emphasizing for more than a decade, the rigor and transparency of a study are key for gleaning the robustness of its results. This includes the design, implementation, analysis, and interpretation of experiments.
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Are you proposing to use key biological and/or chemical resources like cell lines, specialty chemicals, antibodies, or other biologics in your application? Learn more about authentication plans.
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The Advisory Committee to the NIH Director recommended ways for NIH to improve the rigor, reproducibility, and translatability of the research we support involving animal models. I updated the ACD this past June on our implementation of their recommendations. Here, in lieu of going through each of the report’s five themes, I will highlight some approaches raised during the meeting in response to their recommendations.
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NIH expects that sex as a biological variable (SABV) will be factored into research designs, analyses, and reporting in pre-clinical and clinical studies. But, how exactly do you account for SABV? Dr. Chyren Hunter with the NIH Office of Research on Women’s Health explains more in this NIH All About Grants podcast episode.
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We have been busy over the past several months and are happy to announce you can now find helpful resources for stepped wedge group-or cluster-randomized trials (SWGRTs) and more than 15 other study designs and methodological issues on the RMR website.
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To fully benefit from the exponentially growing body of biomedical data, we need cutting-edge approaches that foster data access, analysis, sharing, and collaboration so novel scientific questions can be pursued. But the sheer volume, sometimes siloed nature, along with the costs and time associated with analyzing large datasets, can be difficult for some researchers. Recognizing these concerns, NIH is helping by hosting large data sets and bringing together computational tools and cloud technologies in ways that support open access, interoperability, and collaborative analyses. We encourage you to explore how these resources may help accelerate your research in ways not possible before. Read on for more…
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