October 29, 2024
This summer, the NIH Office of Strategic Coordination launched the new Replication to Enhance Research Impact Initiative, a pilot approach to advance rigor and transparency in biomedical research by supporting the direct third-party replication of NIH-funded studies. Through the new Replication Initiative, we aim to test whether direct replication of selected research studies is a fruitful approach to enhancing research reproducibility, and if yes, for what types of studies, and under what circumstances.
February 9, 2024
Last week, Dr. Monica Bertagnolli accepted recommendations from the Advisory Committee to the NIH Director on considering approaches that use novel alternative methods in biomedical and behavioral research. This is an exciting step in our ongoing efforts to support research that complements traditional models when scientifically feasible.
January 31, 2024
NIH’s Rigor and Reproducibility FAQs have been updated with new questions and answers about authenticating key biological/chemical resources.
October 11, 2023
The NIH office of Laboratory Animal Welfare (OLAW) released a webinar recording on how the NC3Rs Experimental Design Assistant (EDA) can assist researchers plan for their studies involving animals.
September 20, 2023
Earlier this month, we released a Request for Information seeking public input on the humane care and use of laboratory cephalopods at Assured institutions. The proposed guidance acknowledges the evidence suggesting these animals would benefit from oversight, but also that there are not yet specific care and use standards to allow them to be regulated under the Public Health Service Policy for the Humane Care and Use of Laboratory Animals.
August 14, 2023
As NIH has been emphasizing for more than a decade, the rigor and transparency of a study are key for gleaning the robustness of its results. This includes the design, implementation, analysis, and interpretation of experiments.
March 16, 2023
Are you proposing to use key biological and/or chemical resources like cell lines, specialty chemicals, antibodies, or other biologics in your application? Learn more about authentication plans.
February 10, 2023
The Advisory Committee to the NIH Director recommended ways for NIH to improve the rigor, reproducibility, and translatability of the research we support involving animal models. I updated the ACD this past June on our implementation of their recommendations. Here, in lieu of going through each of the report’s five themes, I will highlight some approaches raised during the meeting in response to their recommendations.
July 21, 2022
NIH expects that sex as a biological variable (SABV) will be factored into research designs, analyses, and reporting in pre-clinical and clinical studies. But, how exactly do you account for SABV? Dr. Chyren Hunter with the NIH Office of Research on Women’s Health explains more in this NIH All About Grants podcast episode.
March 14, 2022
We have been busy over the past several months and are happy to announce you can now find helpful resources for stepped wedge group-or cluster-randomized trials (SWGRTs) and more than 15 other study designs and methodological issues on the RMR website.
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