Last week, Dr. Monica Bertagnolli accepted recommendations from the Advisory Committee to the NIH Director on considering approaches that use novel alternative methods in biomedical and behavioral research. This is an exciting step in our ongoing efforts to support research that complements traditional models when scientifically feasible.
At the recent Advisory Committee to the NIH Director (ACD), one of NIH’s newest ACD working groups looking at the issue of Novel Alternative Methods (NAMs) presented a status update. NIH has published a request for information (RFI) to help inform the ACD working group’s deliberations.
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The Advisory Committee to the NIH Director recommended ways for NIH to improve the rigor, reproducibility, and translatability of the research we support involving animal models. I updated the ACD this past June on our implementation of their recommendations. Here, in lieu of going through each of the report’s five themes, I will highlight some approaches raised during the meeting in response to their recommendations.
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The NIH Office of Laboratory Animal Welfare hosted a live webinar in December 2021 entitled, “Best Practices for Conducting a Search for Alternatives and Finding Animal Model/Model Organism Information.”
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Considering alternatives to animals in your application is the topic of our next NIH All About Grants podcast. Drs. Neera Gopee with the NIH Office of Laboratory Animal Welfare and Christine Livingston with the National Center for Advancing Translational Sciences join us for this conversation (MP3 / Transcript). We will go into the 3Rs (replace, refine, and reduce), helpful resources for relevant policies, what’s needed for the vertebrate animal section, role for IACUCs and peer review, as well as organoids, in silico models, and other alternatives…oh my again!
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