In part three of our series on rigor and transparency in research grant and career development award applications, we focus on consideration of relevant biological variables. Updated instructions for the Approach section of the Research Strategy ask the applicant to: ….
In part two of our series on rigor and transparency in research grant and career development award applications, we focus on scientific rigor, the strict application of the scientific method to ensure robust and unbiased experimental design, methodology, analysis, interpretation, and reporting of results. …..
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The NIH recently implemented updates to research grant and career development award applications aimed at enhancing reproducibility through rigor and transparency with a focus on four areas: scientific premise, rigorous experimental design, consideration of relevant biological variables, and authentication of key biological and/or chemical resources. This post is the first in a series addressing each of these four areas, starting with scientific premise. ….
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As you’ve likely heard in the news, NIH received an increase of $2 billion over its 2015 fiscal year budget. With the passage of the 2016 Consolidated Appropriations Act (Public Law 114-113), ….
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As NIH moves ahead with implementing measures to enhance rigor, transparency and reproducibility in NIH-supported research, I’d like to give a brief update on these efforts, and highlight some important timeline changes for implementation in applications for institutional training grants (T), institutional career development awards (K12), and individual fellowships (F). ….
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Are you someone who is interested in making an impact on the future of the biomedical research enterprise? If so, we may have the perfect opportunity for you! We are hiring a deputy director to work with us to lead the NIH Office of Extramural Research (OER). ….
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When it comes to submitting grant applications, the stakes are high – should a submission with errors come in too late, it may be too late to fix. Months of work are lost. Since grant applications are anxiety producing, it is only natural that people would avoid finishing them. But hard facts about how applications fare in peer review when they are submitted closer to the receipt date may give applicants the cognitive tools they need to overcome their inclination to delay. So let’s look at some data…
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On Wednesday, NIH published its strategic plan for fiscal years 2016-2020. We strongly encourage you to take a look at the plan, which focuses on four objectives that will help guide NIH’s priorities over the next five years. The objectives align with many familiar themes for readers of this blog: advance opportunities in biomedical research in fundamental science, treatment and cures, and health promotion and disease prevention; foster innovation by setting NIH priorities to enhance nimbleness, consider burden of disease and value of ….
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On September 11, 2015, the National Heart, Lung, and Blood Institute (NHLBI) announced that it was stopping its Systolic Pressure Intervention Trial (“SPRINT”). The Institute’s Data Safety and Monitoring Board (DSMB) had reviewed interim data and concluded that the results demonstrated clear benefit from aggressive blood pressure lowering. The trial enrolled over 9300 adults with systolic hypertension and increased cardiovascular risk and randomized them to standard control (aiming for a target systolic blood pressure of 140 mm Hg) or to aggressive control (aiming for a target blood pressure of 120 mm Hg). ….
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In 2014, NIH announced plans for policy changes to ensure that NIH-supported investigators consider relevant measures, including sex as a biological variable (SABV), in preclinical research. NIH solicited feedback through a request for information, and we invited the research community to participate in workshops and resource development. These activities led to new guidelines for addressing SABV as an aspect of rigor and reproducibility in NIH research project grant applications and mentored career development award applications due January 25, 2016, and beyond. As you prepare applications and think about addressing the new instructions we wanted to offer some reminders about the policy’s origin, and about the application and review information. In particular, we wanted to point out what including SABV does not mean. ….
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