As part of our efforts to strengthen rigor of NIH-supported research involving animal models, the NIH Office of Laboratory Animal Welfare recently hosted an informative webinar that provided an overview of the ARRIVE Essential 10, how each relates to study quality, and how to operationalize them for inclusion in research protocols and grant proposals. The “Essential 10” are statistically-based items essential for ensuring study rigor and reproducibility. However, reporting is not enough – study quality and reliability can be achieved only if these items are built into the study before data are collected.
NIH aims to have all of its supported research, including that involving animal models, to be rigorously performed and able to be reproduced. As Dr. Michael Lauer, NIH Deputy Director for Extramural Research, said in this blog from February, “We are committed to ensuring our supported research is of the highest quality, efficient, explainable, and can be repeated by others, thereby increasing the validity of the scientific findings. When experiments involving animals are designed with rigor, the results are more likely to be replicated in future studies and translate in ways that improve the health of humans.” The webinar recording and supporting materials are available on the NIH Office of Laboratory Welfare website.