In 2014, NIH published an NIH Guide Notice on Modification to Guidance on Marking Changes in Resubmission Applications. The notice highlights that NIH has removed the requirement to identify ‘substantial scientific changes’ in the text of a Resubmission application by ‘bracketing, indenting, or change of typography’. Please read NOT-OD-15-030 for more information, and find answers to more frequently asked questions regarding application resubmission on the grants.nih.gov website.
To make it easier for your reviewers to see what has changed in your resubmitted application, mark the substantial scientific changes by bracketing, indenting, or italicizing or changing the font (to one of the other acceptable fonts). Please do not underline or shade the changes. Deleted sections should be described but not marked as deletions. If the changes are so extensive that essentially all of the text would be marked, explain this in the introduction and don’t mark the changes.