Outcomes for R01 “Virtual A2s”

A few months ago, a researcher told me about his experiences with the relatively new NIH policy by which investigators are allowed to submit what we have come to call “virtual A2s.” Under NIH’s previous single resubmission policy, if an investigator’s de novo R01 grant application (called an “A0”) was not funded, they had one chance to submit a revision (called an “A1”). If the A1 application was unsuccessful, the applicant was required to make significant changes in the application compared to the previous submissions. NIH took measures to turn away subsequent submissions that were materially similar to the unfunded A1. Under NIH’s current policy, investigators may resubmit a materially similar application as a new submission after the A1 submission. We will call these applications “virtual A2s.” The researcher told me that his virtual A2 did not fare well; although his A0 and A1 had received good scores (though not good enough for funding), the virtual A2 was not discussed. He wondered, just how likely is it for a virtual A2 to be successful? …. Continue reading

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