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The National Institute of Allergy and Infectious Diseases recently posted 4 funded R21 applications and their summary statements, along with some tips and advice for applying for R21s. Check out the article and the samples.
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“But people also submit more mainstream applications for projects that are smaller than would be appropriate for an R01, as did the PIs who wrote our four sample applications.”
This is the problem, you see. If an R21 is just an R01 with a smaller budget, the “high risk” element disappears. Preliminary data are now a de facto requirement of R21 submissions, contributing to the problem. I also note that NIH funds a disproportionate amount of cell-level versus human being-level (and virtually no health system-level) research, suggesting that the molecular biology and biochemistry components receive undue weight.
So, in short, not helpful, no.