New applications show new direction and scope through changes to all components of the research plan. Such changes include a substantial change in aims, the questions asked, the approach and/or methods that will be used to address the research questions, and, consequently, the potential outcomes that might be expected from the work.
NIH carefully examines any application that appears to be another version of an application that has exhausted its resubmission opportunities, or an application with significant scientific overlap with another application. Even if changed from previous submissions, applications may not be considered new if many of the hypotheses, aims, and/or outcome measures are the same or highly similar.
To understand more about how NIH determines if an application is considered new, see a new resource developed by NIH’s Center for Scientific Review here.