NIH Director Elias Zerhouni, M.D. recently announced a new program to be conducted through the NIH Roadmap that is designed to stimulate the disruption of existing research paradigms or create research paradigms where none now exist. The idea for such a program has been in the works since its genesis in the 2003 NIH Roadmap planning effort, through discussions at various public workshops, and through suggestions made during the enhancing peer review effort.
The Transformative R01 Program (T-R01s) will allow highly creative, “out-of-the-box” projects to be supported in any area of research that falls within the NIH mission, and in particular, in areas of Highlighted Need. The NIH recognizes that new paradigms are needed in these areas and will highly encourage research that addresses these needs. The broad topics to be highlighted include:
- Understanding and Incenting Behavior Change
- 3-D Tissue Models
- Functional Variation in Mitochondria
- Transition from Acute to Chronic Pain
- Formulation of novel protein capture reagents
The T-R01 Program represents a High Risk/High Reward Demonstration Project in which novel approaches to peer review and program management are to be piloted. Look for a funding opportunity to be published in the next few weeks!
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